| Subject |
Carbohydrate drugs.
|
| Descript |
1 online resource (242 p.) |
| Note |
Description based upon print version of record. |
| Contents |
Preface -- Contents -- Carbohydrate-Based Synthetic Chemistry in the Context of Drug Design -- 1 Introduction -- 2 Carbohydrate Mimics -- 2.1 C-Glycosides via Pd-Catalyzed Cross-Couplings -- 2.2 Carbohydrates with Reduced Conformational Flexibility of the 6-Hydroxyl Group -- 2.3 Synthesis of Carbohydrate-Derived [n,5]-Spiroketals -- 2.4 Hybrids of Carbohydrates and Arenes -- 2.4.1 Synthesis of Chromans and Isochromans via Domino Carbopalladation Reactions -- 2.4.2 Synthesis of Anthracycline Derivatives -- 3 Conclusion -- References |
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Iminosugars: Therapeutic Applications and Synthetic Considerations -- 1 Introduction -- 2 Iminosugars: Classification, Occurrence and Historical Context -- 3 Glycospace and the Drug Target Landscape -- 3.1 Glycospace: A Source of New Medicines -- 3.2 Glycomimetics as Modulators of Carbohydrate Biology -- 3.3 Glycomimetics: Stereochemical and Structural Considerations -- 3.4 Iminosugars: The Glycomimetic of Choice -- 3.5 Iminosugars: Therapeutic Perspective -- 4 Strategies for the Synthesis of Iminosugars -- 5 Iminosugars: Drug-Like Properties, Concepts, Structure Design and Application |
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5.1 Glucocerebrosidase: A Druggable Target -- 5.2 Iminosugar Chaperones for Therapeutic Intervention -- 6 Summary, Conclusions, Outlook -- References -- Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs -- 1 Introduction -- 2 The Application of Docking Methods in Carbohydrate-Based Drug Design -- 2.1 Basics, Limitations, and Pitfalls -- 2.2 What Makes Docking of Carbohydrates Challenging? -- 2.3 Docking of Modified Carbohydrates: A Practical Guide -- 2.4 Predicting Carbohydrate Binding Sites: A Practical Example -- 3 Summary, Conclusions, Outlook -- References |
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Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagliflozin for the Treatment ... -- 1 Introduction -- 2 Results and Discussion -- 2.1 Discovery -- 2.2 Chemistry -- 3 Summary, Conclusions, Outlook -- References -- Design, Synthesis, and Applications of Galectin Modulators in Human Health -- 1 Introduction -- 2 Galectin CRD Structure and Ligand Subsites -- 3 Galectin Modulators -- 3.1 Small Molecule Galectin-3 Modulators Targeting Subsites A-D -- 3.2 Small Molecule Galectin Modulators Targeting Subsite C-E |
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3.3 Small Molecule Galectin Modulators Targeting Subsites A-E -- 3.4 Small Molecule Galectin Modulators Targeting Alternative Subsite Combinations -- 4 Galectin-3 Modulator Biological Effects -- 4.1 Galectin-3 Modulators in Chronic Inflammation and Fibrosis -- 4.1.1 Modulating Macrophage M2 Differentiation -- 4.1.2 Modulating Myofibroblast Activation and Fibrosis -- 4.2 Galectin-3 Modulators in Angiogenesis -- 5 Summary, Conclusions, Outlook -- References -- Discovery and Application of FimH Antagonists -- 1 Introduction -- 2 Discoveries -- 2.1 The Mannose-Binding Lectin on the Surface of E. coli |
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2.2 FimH Recognizes Short N-Linked High-Mannose Glycans on Protein Receptors |
| Note |
325 annual accesses. UkHlHU |
| Alt author |
Rademacher, Christoph.
|
| ISBN |
9783319086750 |
|
