| Subject |
Cancer cells.
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Tumors.
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| Descript |
1 online resource (171 pages) |
| Content |
text txt |
| Media |
computer c |
| Carrier |
online resource cr |
| Contents |
Intro -- Preface -- References for general reading on history of Tumor Microenvironment: -- Contents -- About the Editors -- Inflammatory Components of the Thyroid Cancer Microenvironment: An Avenue for Identification of Novel Biomarkers -- 1 Tumor Microenvironment of Solid Tumors -- 1.1 Defining the Tumor Microenvironment -- 1.2 Cellular Constituents of the Tumor Microenvironment -- 1.2.1 Cancer-Associated Fibroblasts (CAFs) -- 1.2.2 Endothelial Cells (ECs) -- 1.2.3 Cancer Stem Cells (CSCs) -- 1.2.4 Immune Cells -- 1.3 Immune Cells of the Tumor Microenvironment -- 1.3.1 Natural Killer Cells (NK Cells) -- 1.3.2 Dendritic Cells -- 1.3.3 Mast Cells -- 1.3.4 T Regulatory Cells (Tregs) -- 1.3.5 CD8+ Cytotoxic T Cells (CTLs) -- 1.3.6 Tumor-Associated Macrophages (TAMs) -- 2 Specificity of the Thyroid Tumor Microenvironment -- 2.1 Anatomy of the Thyroid Gland -- 2.2 Thyroid Cancer -- 2.3 Heterogeneity of Thyroid Cancer Cells -- 2.4 Anaplastic Thyroid Cancer -- 2.5 Amplified Metastatic Propensity of Anaplastic Thyroid Cancer -- 2.6 Thyroid Cancer and Inflammation -- 2.7 Dynamic Nature of the Thyroid Tumor Microenvironment -- 2.8 Immune Cell Remodeling of the Thyroid Tumor Microenvironment -- 2.9 Immune Surveillance in the Thyroid Tumor Microenvironment -- 2.10 Evolution of the Metastatic Phenotype Via Macrophages -- 2.11 Interacting Molecules of the Thyroid Tumor Microenvironment -- 2.11.1 Cytokines and Chemokines -- 2.11.2 Exosomes -- 3 Cellular Communication in the Tumor Microenvironment -- 4 Future Directions -- 4.1 Novel Targets of Therapeutic Intervention -- References -- Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity -- 1 Tumor Microenvironment -- 2 Cellular Constituents -- 2.1 Immune Cells -- 2.1.1 Macrophages -- 2.1.2 Dendritic Cells (DCs). |
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2.1.3 Natural Killer (NK) Cells -- 2.1.4 T Lymphocytes -- 2.2 Nonimmune Cells -- 2.2.1 Neuroendocrine Cells -- 2.2.2 Adipose Cells -- 2.2.3 Endothelial Cells -- 2.2.4 Mesenchymal Cells -- 2.2.5 Fibroblasts -- 3 Dynamic Nature of the Tumor Microenvironment -- 4 Specificity of the Thyroid Tumor Microenvironment -- 4.1 Immune Landscape in Anaplastic Thyroid Cancer -- 4.2 Immune Surveillance in Thyroid Cancer -- 4.3 Evolution of the Metastatic Phenotype -- 4.4 Interacting Molecules -- 4.4.1 ATC Has a Complex Cytokine Milieu -- 4.4.2 Immune Targets on the Tumor and Its Tripartite Cell-Cell Communication -- 4.4.3 T Cell Co-signaling Molecules -- 4.4.4 Immune Checkpoint Molecules in Cancer -- 4.4.5 ATC Has T Cell-Inflamed Immune Microenvironment -- 4.4.6 Immune Modulatory Molecules in ATC: An Unexplored Realm -- 5 Consequences of Three-Way Communication -- 5.1 Inflammation and Immune Checkpoint Molecules: A Complex Interplay -- 6 HVEM/CD160/BTLA Axis in ATC -- 6.1 Novel Targets of Therapeutic Intervention -- 7 HVLA/BTEM Axis as Potential Therapeutic Target -- 8 Importance of TME Interacting Components Targets -- 9 Further Studies in ATC: Cytokines, miRNAs, Exosomes, etc. -- References -- Exosomes in the Healthy and Malignant Bone Marrow Microenvironment -- 1 The Bone Marrow Microenvironment -- 1.1 Endosteal Niche -- 1.2 Perivascular Niche -- 2 Exosomes -- 2.1 Characterization -- 2.2 Biogenesis -- 2.3 Cargo -- 2.4 Docking and Release -- 2.5 Uptake and Downstream Effects -- 3 Bone Marrow-Associated Cancers -- 4 Microenvironment in Maintaining Cancer Stem Cells -- 5 Exosome-Mediated Communication: Hematologic Malignancies -- 5.1 Endothelial Cells -- 5.2 Mesenchymal Stem Cells (MSCs) -- 5.3 Macrophages -- 5.4 Osteoblasts -- 6 Exosome-Mediated Communication: Bone Marrow-Metastatic Breast Cancer. |
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6.1 Endothelial Cells -- 6.2 Mesenchymal Stem Cells -- 6.3 Macrophages -- 6.4 Osteoblasts -- 7 Therapeutic Strategies -- 7.1 Current Therapies -- 7.2 Exosome-Based Therapies -- 7.3 Limitations of Exosome-Based Therapies -- 7.4 3D BMM: In Vitro Approaches to Improve Clinical Efficacy -- 8 Conclusion -- References -- Structural Biology of the Tumor Microenvironment -- 1 Structural Biology of the TME -- 2 Cellular Elements -- 2.1 Fibroblasts -- 2.2 Adipocytes -- 2.3 Vascular Endothelial Cells -- 2.4 Pericytes -- 2.5 Lymphatic Endothelial Cells -- 2.6 Immune Cells -- 3 Structural Elements -- 3.1 Vasculature -- 3.2 Extracellular Matrix -- 3.3 ECM Structural Proteins -- References -- Metabolic Interactions Between Tumor and Stromal Cells in the Tumor Microenvironment -- 1 Introduction -- 2 Metabolic Alterations in Cancer Cells -- 3 Signaling Pathways Promoting Metabolic Alterations in Tumor -- 4 Signaling Pathway Alterations in Tumor-Associated Stroma -- 5 Stromal Heterogeneity in the Tumor Microenvironment -- 6 CAFs as Mediators of Tumor-Stroma Interaction -- 7 Chemokines in Driving Tumor-Stroma Interactions -- 8 Lactate in Driving Tumor-Stroma Interactions -- 9 Epigenetic Reprogramming in the Tumor Microenvironment -- 10 Therapeutic Targeting of Molecular Interaction Between Tumor and Stroma -- 11 Conclusion -- References -- Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy -- 1 Types of Melanoma -- 2 Therapeutic Options -- 3 Genetic Lesions and Immunogenicity in Melanoma -- 4 The Melanoma Tumor Microenvironment -- 4.1 Immunoglobulin Superfamily -- 4.2 Tumor Necrosis Factor Receptor Superfamily -- 5 Expression of Immune Targets on Melanoma Cells -- 6 Perspectives -- 7 HVEM/BTLA/CD160 Interactome -- References. |
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Noncoding RNAs in Papillary Thyroid Cancer: Interaction with Cancer-Associated Fibroblasts (CAFs) in the Tumor Microenvironment (TME) and Regulators of Differentiation and Lymph Node Metastasis -- 1 Introduction -- 1.1 Overview of the Thyroid Gland -- 1.1.1 Normal Thyroid Differentiation and Thyroid Hormone Synthesis -- 1.1.2 Thyroid Hormone Production and Regulation -- 1.2 Papillary Thyroid Carcinoma -- 1.2.1 Classification of Thyroid Cancers -- 1.3 Diagnostic and Therapeutic Approach to Thyroid Nodules -- 1.3.1 Initial Evaluation of a Thyroid Nodule -- 1.3.2 FNA and Current Molecular Classifiers -- 1.3.3 Treatment Modalities -- 1.3.4 Potential Role of Novel Biomarkers -- 1.4 lncRNAs in Papillary Thyroid Cancer -- 1.4.1 Structure and Function of lncRNAs -- 1.4.2 lncRNA Investigation in Papillary Thyroid Cancer -- 2 lncRNAs Highly Associated with Thyroid Differentiation and Tissue-Specific Expression -- 3 lncRNAs Expressed in Primary Tumors that Predict LNM -- 4 lncRNas as Regulators of Molecular Phenotype and Interaction with Components of TME -- References -- Index. |
| Alt author |
Tiwari, Raj K.
|
| ISBN |
9783030832827 (electronic bk.) |
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